The Role of Aneuploidy Screening in Human Preimplantation Embryos
نویسندگان
چکیده
Aneuploidy can be defined as extra or missing whole chromosomes in the nucleus of a cell and occurs during cell division when chromosomes do not separate equally between the two new daughter cells (Hassold & Hunt 2001). Chromosome imbalance typically results in non-viability, manifesting as developmental arrest prior to implantation, miscarriage or stillbirth. Depending on the chromosomes involved, aneuploidy can also result in viable but developmentally abnormal pregnancies e.g. Down or Klinefelter Syndrome. In all cases, aneuploidy results in a non-favourable outcome for the family in question and is undoubtedly a major contributing factor to the relatively low fecundity of humans when compared with other species.
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